| Rank | Player | Date | Opponent | Blocks
|
|---|
| 1
| Khaleann Caron-Goudreau, Laval | Mar 9, 2019 | Ottawa | 10 |
| 2
| Leanne Evans, UBC | Mar 1, 2008 | Regina | 9 |
| 3
| Claire Signatovich, Alberta | Feb 18, 2023 | UFV | 9 |
| 4
| Dalyce Emmerson, Saskatchewan | Mar 8, 2014 | UFV | 8 |
| 5
| Alexandria Kiss-Rusk, McGill | Mar 10, 2016 | Concordia | 8 |
| 6
| Angela Ribarich, Ottawa | Feb 24, 2018 | Queen's | 8 |
| 7
| Alexandra Berry, Acadia | Mar 8, 2018 | Saskatchewan | 8 |
| 8
| Jessica Foltinek, Calgary | Feb 15, 2003 | UBC | 7 |
| 9
| Jessica Clemencon, Windsor | Mar 20, 2011 | Saskatchewan | 7 |
| 10
| Christina McCusker, Regina | Feb 23, 2017 | Trinity Western | 7 |
| 11
| Sarah Crooks, Saskatchewan | Feb 25, 2006 | Calgary | 6 |
| 12
| Julia Wilson, Simon Fraser | Feb 17, 2007 | Victoria | 6 |
| 13
| Hannah Sunley-Paisley, Ottawa | Feb 20, 2010 | Ryerson | 6 |
| 14
| Denisha Haywood, Cape Breton | Mar 20, 2011 | StFX | 6 |
| 15
| Nicole Karstein, Victoria | Feb 28, 2016 | Trinity Western | 6 |
| 16
| Dalyce Emmerson, Saskatchewan | Mar 19, 2016 | Saint Mary's | 6 |
| 17
| Christina McCusker, Regina | Feb 21, 2019 | Calgary | 6 |
| 18
| Oksana Gouchie-Provencher, Ottawa | Feb 22, 2023 | Laurentian | 6 |
| 19
| Julia Wilson, Simon Fraser | Feb 23, 2007 | UBC | 5 |
| 20
| Jessica Clemencon, Windsor | Mar 3, 2010 | Western | 5 |
| 21
| Sarah Semeniuk, Victoria | Feb 26, 2011 | Regina | 5 |
| 22
| Nicki Schutz, Toronto | Mar 20, 2011 | Laurier | 5 |
| 23
| Iva Peklova, Windsor | Mar 2, 2012 | Carleton | 5 |
| 24
| Nicole Rosenkranz, Brock | Mar 2, 2012 | Ottawa | 5 |
| 25
| Jessica Clemencon, Windsor | Mar 3, 2012 | Ottawa | 5 |
|
|
| Rank | Player | Date | Opponent | Blocks
|
|---|
| 26
| Jessica Clemencon, Windsor | Mar 16, 2013 | Calgary | 5 |
| 27
| Mariam Sylla, McGill | Mar 16, 2013 | UFV | 5 |
| 28
| Megan Vande Kraats, Alberta | Mar 8, 2014 | Regina | 5 |
| 29
| Sarah Wierks, UFV | Mar 14, 2014 | McGill | 5 |
| 30
| Cheyanne Roger, Windsor | Feb 28, 2015 | Toronto | 5 |
| 31
| Cheyanne Roger, Windsor | Mar 6, 2015 | Lakehead | 5 |
| 32
| Kelly Fagan, MacEwan | Mar 5, 2016 | Victoria | 5 |
| 33
| Cheyanne Roger, Windsor | Mar 5, 2016 | Carleton | 5 |
| 34
| Dalyce Emmerson, Saskatchewan | Mar 20, 2016 | Ryerson | 5 |
| 35
| Christina McCusker, Regina | Feb 22, 2019 | Calgary | 5 |
| 36
| Olivia Wilson, McMaster | Feb 28, 2019 | Carleton | 5 |
| 37
| Claire Signatovich, Alberta | Feb 20, 2020 | UFV | 5 |
| 38
| Inga Aleksaite, UQAM | Feb 26, 2020 | Bishop's | 5 |
| 39
| Samantha Keltos, Brock | Mar 7, 2020 | UPEI | 5 |
| 40
| Khaleann Caron-Goudreau, Laval | Mar 8, 2020 | UPEI | 5 |
| 41
| Clare Sharkey, McMaster | Mar 16, 2022 | Waterloo | 5 |
| 42
| Sarah Harvey, Western | Mar 23, 2022 | Brock | 5 |
| 43
| Madalyn Weinert, Brock | Mar 26, 2022 | Ryerson | 5 |
| 44
| Madalyn Weinert, Brock | Apr 2, 2022 | Ryerson | 5 |
| 45
| Julia Tuchscherer, UFV | Feb 18, 2023 | Alberta | 5 |
| 46
| Clara Gascoigne, Saint Mary's | Feb 25, 2023 | UPEI | 5 |
| 47
| Oksana Gouchie-Provencher, Ottawa | Feb 25, 2023 | Waterloo | 5 |
| 48
| Claire Signatovich, Alberta | Mar 4, 2023 | Calgary | 5 |
| 49
| Claire Signatovich, Alberta | Mar 12, 2023 | Saint Mary's | 5 |
| 50
| Claire Signatovich, Alberta | Feb 22, 2024 | Calgary | 5 |
|