| Rank | Player | Date | Opponent | Blocks
|
|---|
| 1
| Samantha Keltos | Jan 29, 2020 | York | 9 |
| 2
| Madison MacInnis | Jan 31, 2025 | Lakehead | 7 |
| 3
| Samantha Keltos | Feb 8, 2020 | Waterloo | 6 |
| 4
| Samantha Keltos | Feb 15, 2020 | Carleton | 6 |
| 5
| Nicole Rosenkranz | Nov 15, 2013 | Ottawa | 6 |
| 6
| Madalyn Weinert | Feb 17, 2024 | Nipissing | 6 |
| 7
| Ashantae Gayle | Feb 4, 2023 | Guelph | 5 |
| 8
| Samantha Keltos | Jan 19, 2020 | Windsor | 5 |
| 9
| Samantha Keltos | Nov 20, 2021 | Windsor | 5 |
| 10
| Nicole Rosenkranz | Nov 11, 2011 | Ottawa | 5 |
| 11
| Nicole Rosenkranz | Nov 16, 2013 | Carleton | 5 |
| 12
| Nicole Rosenkranz | Nov 30, 2013 | Waterloo | 5 |
| 13
| Madalyn Weinert | Jan 21, 2023 | York | 5 |
| 14
| Madalyn Weinert | Oct 24, 2025 | Toronto | 5 |
| 15
| Kira Cornelissen | Nov 28, 2015 | Lakehead | 4 |
| 16
| Kira Cornelissen | Jan 7, 2017 | Nipissing | 4 |
| 17
| Samantha De Jong | Jan 3, 2013 | McMaster | 4 |
| 18
| Samantha De Jong | Feb 9, 2013 | Guelph | 4 |
| 19
| Shannon Hann | Jan 30, 1999 | McMaster | 4 |
| 20
| Madison MacInnis | Nov 11, 2022 | Lakehead | 4 |
| 21
| Nicole Rosenkranz | Dec 2, 2011 | Ryerson | 4 |
| 22
| Nicole Rosenkranz | Feb 6, 2013 | Laurier | 4 |
| 23
| Nicole Rosenkranz | Jan 24, 2014 | Lakehead | 4 |
| 24
| Madalyn Weinert | Feb 16, 2022 | McMaster | 4 |
| 25
| Madalyn Weinert | Dec 2, 2022 | Carleton | 4 |
|
|
| Rank | Player | Date | Opponent | Blocks
|
|---|
| 26
| Madalyn Weinert | Nov 25, 2023 | McMaster | 4 |
| 27
| Madalyn Weinert | Dec 1, 2023 | Waterloo | 4 |
| 28
| Madalyn Weinert | Dec 2, 2023 | Laurier | 4 |
| 29
| Madalyn Weinert | Nov 9, 2024 | Waterloo | 4 |
| 30
| Madalyn Weinert | Nov 14, 2025 | Windsor | 4 |
| 31
| Madalyn Weinert | Jan 19, 2026 | Lakehead | 4 |
| 32
| Madalyn Weinert | Jan 24, 2026 | Queen's | 4 |
| 33
| Bridget Atkinson | Feb 1, 2017 | Waterloo | 3 |
| 34
| Kira Cornelissen | Jan 20, 2016 | Western | 3 |
| 35
| Kira Cornelissen | Dec 3, 2016 | Ottawa | 3 |
| 36
| Samantha De Jong | Jan 26, 2011 | Guelph | 3 |
| 37
| Samantha De Jong | Nov 16, 2012 | Carleton | 3 |
| 38
| Samantha De Jong | Nov 16, 2013 | Carleton | 3 |
| 39
| Samantha De Jong | Feb 1, 2014 | Laurier | 3 |
| 40
| Whitney Gorges | Nov 26, 2010 | York | 3 |
| 41
| Kate Harpur | Jan 27, 2016 | Guelph | 3 |
| 42
| Samantha Keltos | Nov 27, 2021 | Guelph | 3 |
| 43
| Samantha Keltos | Feb 16, 2022 | McMaster | 3 |
| 44
| Madison MacInnis | Nov 4, 2022 | Toronto | 3 |
| 45
| Madison MacInnis | Jan 7, 2023 | Ontario Tech | 3 |
| 46
| Madison MacInnis | Jan 27, 2023 | Nipissing | 3 |
| 47
| Madison MacInnis | Feb 3, 2023 | Toronto | 3 |
| 48
| Madison MacInnis | Feb 11, 2023 | Western | 3 |
| 49
| Madison MacInnis | Jan 20, 2024 | Ontario Tech | 3 |
| 50
| Madison MacInnis | Jan 26, 2024 | Lakehead | 3 |
|