| Rank | Player | Date | Opponent | Blocks
|
|---|
| 1
| Samantha Keltos | Mar 7, 2020 | UPEI | 5 |
| 2
| Nicole Rosenkranz | Mar 2, 2012 | Ottawa | 5 |
| 3
| Madalyn Weinert | Mar 26, 2022 | Ryerson | 5 |
| 4
| Madalyn Weinert | Apr 2, 2022 | Ryerson | 5 |
| 5
| Shannon Northey | Feb 22, 2017 | Lakehead | 4 |
| 6
| Madalyn Weinert | Apr 3, 2022 | Queen's | 4 |
| 7
| Madalyn Weinert | Feb 22, 2025 | Toronto Metropolitan | 4 |
| 8
| Samantha De Jong | Feb 25, 2012 | Laurier | 3 |
| 9
| Samantha De Jong | Mar 3, 2012 | Carleton | 3 |
| 10
| Samantha Keltos | Feb 22, 2020 | Windsor | 3 |
| 11
| Samantha Keltos | Mar 5, 2020 | Calgary | 3 |
| 12
| Madalyn Weinert | Mar 23, 2022 | Western | 3 |
| 13
| Allison Addy | Mar 31, 2022 | Acadia | 2 |
| 14
| Kira Cornelissen | Mar 2, 2016 | Guelph | 2 |
| 15
| Stacey Farr | Mar 1, 2002 | McMaster | 2 |
| 16
| Victoria Lawrence | Mar 26, 2022 | Ryerson | 2 |
| 17
| Madison MacInnis | Mar 23, 2022 | Western | 2 |
| 18
| Madison MacInnis | Feb 22, 2023 | Windsor | 2 |
| 19
| Madison MacInnis | Feb 24, 2024 | Toronto Metropolitan | 2 |
| 20
| Madison MacInnis | Feb 19, 2025 | Laurentian | 2 |
| 21
| Andrea Polischuk | Feb 19, 2014 | Laurier | 2 |
| 22
| Nicole Rosenkranz | Mar 9, 2012 | Saskatchewan | 2 |
| 23
| Kayla Santilli | Mar 3, 2012 | Carleton | 2 |
| 24
| Madalyn Weinert | Mar 31, 2022 | Acadia | 2 |
| 25
| Madalyn Weinert | Feb 22, 2023 | Windsor | 2 |
|
|
| Rank | Player | Date | Opponent | Blocks
|
|---|
| 26
| Allison Addy | Feb 24, 2024 | Toronto Metropolitan | 1 |
| 27
| Allison Addy | Feb 19, 2025 | Laurentian | 1 |
| 28
| Jamie Addy | Feb 18, 2026 | McMaster | 1 |
| 29
| Baelie Campbell | Feb 22, 2017 | Lakehead | 1 |
| 30
| Samantha De Jong | Mar 9, 2012 | Saskatchewan | 1 |
| 31
| Jessica Del Signore | Feb 23, 2011 | Lakehead | 1 |
| 32
| Jessica Del Signore | Mar 3, 2012 | Carleton | 1 |
| 33
| Kaley DeMont | Mar 19, 2022 | McMaster | 1 |
| 34
| Kaley DeMont | Mar 31, 2022 | Acadia | 1 |
| 35
| Eden Ferraro | Feb 22, 2020 | Windsor | 1 |
| 36
| Eden Ferraro | Mar 5, 2020 | Calgary | 1 |
| 37
| Eden Ferraro | Mar 7, 2020 | UPEI | 1 |
| 38
| Aryn Finley | Mar 2, 2016 | Guelph | 1 |
| 39
| Kristin Gallant | Mar 8, 2020 | Saskatchewan | 1 |
| 40
| Whitney Gorges | Feb 24, 2010 | McMaster | 1 |
| 41
| Kate Harpur | Mar 2, 2016 | Guelph | 1 |
| 42
| Janee Harrison | Feb 18, 2026 | McMaster | 1 |
| 43
| Mary Ivison | Mar 8, 2020 | Saskatchewan | 1 |
| 44
| Samantha Keltos | Feb 26, 2020 | Western | 1 |
| 45
| Madison MacInnis | Mar 19, 2022 | McMaster | 1 |
| 46
| Madison MacInnis | Apr 3, 2022 | Queen's | 1 |
| 47
| Emily McKay | Feb 27, 2010 | Windsor | 1 |
| 48
| Emily McKay | Mar 2, 2012 | Ottawa | 1 |
| 49
| Courtney McPherson | Feb 20, 2019 | Laurier | 1 |
| 50
| Jenneke Pilling | Mar 23, 2022 | Western | 1 |
|